Description
Product Characteristics: AF6 is a Ras target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL in leukemias caused by t(6,11) translocations. Synonyms: Polyclonal MLLT4 antibody, Anti-MLLT4 antibody, myeloid/lymphoid or mixed-lineage leukemia, translocated to, 4 antibody, RP3-470B24.4 antibody, AF-6 antibody, AF6 antibody, AFADIN antibody, FLJ34371 antibody, RP3-431P23.3 antibody.
Target Information: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6\,11)(q27\,q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]